We study the molecular mechanism and in vivo function of nucleotide excision repair (NER). Our research focuses on:

  • Molecular NER machinery
  • NER organization in vivo and in differentiated cell types
  • NER activity in response to cancer chemotherapeutics
  • The impact of mutations in NER genes on health
  • interplay of NER with other DNA repair mechanisms
  • NER function within chromatin


Recent news

We published our protocol detailing how UV survival assays in C. elegans can be used to distinguish between global genome and transcription-coupled nucleotide excision repair in STAR protocols.

 

We collaborated on a paper published in Nature Cell Biology showing that ELOF1 is a new transcription-coupled DNA repair factor.

 

Amazing Erasmus MC, an online magazine on everything that goes on in our host institute Erasmus MC, has published very nice short cover story in Dutch about our DNA repair work with C. elegans.

C2W, the online magazine of the Royal Netherlands Chemical Society, wrote a short article (originally in Dutch but here also in English) explaining our recent findings on tissue-specific DNA repair in C. elegans.

We published a paper in Cell Reports describing intriguing differences in DNA repair and DNA damage response in different tissues of the model organism C. elegans.

We published a paper in Nature Communications showing that DDB2 dissociation promotes DNA damage handover to XPC-TFIIH.

On 9 June 2020, Cristina Ribeiro-Silva successfully defended her thesis ‘Nucleotide excision repair through the looking glass’ online.

On 23 October 2019 Mariangela Sabatella succesfully defended her thesis entitled ‘When a cut makes the difference: DNA damage incision from human cells to C. elegans.‘

We collaboratively published a comprehensive review in Nature Reviews Molecular Cell Biology about the DNA damage response to transcription stress