Publications

Llerena Schiffmacher DA, Lee SH, Kliza KW, Theil AF, Akita M, Helfricht A, Bezstarosti K, Gonzalo-Hansen C, van Attikum H, Verlaan-de Vries M, Vertegaal ACO, Hoeijmakers JHJ, Marteijn JA, Lans H, Demmers JAA, Vermeulen M, Sixma TK, Ogi T, Vermeulen W, Pines A (2024) The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics.
Nature Communications 15:6374. 10.1038/s41467-024-50584-7
 
Gonzalo-Hansen C, Steurer B, Janssens RC, Zhou D, van Sluis M, Lans H, Marteijn JA (2024) Differential processing of RNA polymerase II at DNA damage correlates with transcription-coupled repair syndrome severity.
Nucleic Acids Research 10.1093/nar/gkae618
 
Muniesa-Vargas A, Davó-Martínez C, Ribeiro-Silva C, van der Woude M, Thijssen KL, Haspels B, Häckes D, Kaynak ÜU, Kanaar R, Marteijn JA, Theil AF, Kuijten MMP, Vermeulen W, Lans H (2024) Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure.
Nature Communications 15:3490 10.1038/s41467-024-47935-9
 
van Sluis M, Yu Q, van der Woude M, Gonzalo-Hansen C, Dealy SC, Janssens RC, Somsen HB, Ramadhin AR, Dekkers DHW, Wienecke HL, Demmers JJPG, Raams A, Davó-Martínez C, Llerena Schiffmacher DA, van Toorn M, Häckes D, Thijssen KL, Zhou D, Lammers JG, Pines A, Vermeulen W, Pothof J, Demmers JAA, van den Berg DLC, Lans H, Marteijn JA (2024) Transcription-coupled DNA-protein crosslink repair by CSB and CRL4CSA-mediated degradation.
Nature Cell Biol 10.1038/s41556-024-01394-y
 
Slyskova J, Muniesa-Vargas A, da Silva IT, Drummond R, Park J, Häckes D, Poetsch I, Ribeiro-Silva C, Moretton A, Heffeter P, Schärer OD, Vermeulen W, Lans H, Loizou JI (2023) Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy.
NAR Cancer 5:zcad057 10.1093/narcan/zcad057
 
Theil AF, Pines A, Kalayci T, Heredia-Genestar JM, Raams A, Rietveld MH, Sridharan S, Tanis SE, Mulder KW, Büyükbabani N, Karaman B, Uyguner ZO, Kayserili H, Hoeijmakers JH, Lans H, Demmers JA, Pothof J, Altunoglu U, El Ghalbzouri A, Vermeulen W (2023) Trichothiodystrophy-associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation.
EMBO Mol Med 15:e17973 10.15252/emmm.202317973
 
van der Woude M, Davó-Martínez C, Thijssen KL, Vermeulen W, Lans H (2023)Recovery of protein synthesis to assay DNA repair activity in transcribed genes in living cells and tissues.
Nucleic Acids Research 51:e9310.1093/nar/gkad642
 
Davó-Martínez C, Helfricht A, Ribeiro-Silva C, Raams A, Tresini M, Uruci S, van Cappellen WA, Taneja N, Demmers JAA, Pines A, Theil AF, Vermeulen W, Lans H (2023) Different SWI/SNF complexes coordinately promote R-loop- and RAD52-dependent transcription-coupled homologous recombination.
Nucleic Acids Research 51:9055-9074  10.1093/nar/gkad609
 
Crossley MP, Song C, Bocek MJ, Choi JH, Kousorous J, Sathirachinda A, Lin C, Brickner JR, Bai G, Lans H, Vermeulen W, Abu-Remaileh M, Cimprich KA (2023) R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response.
Nature 613:187-194 10.1038/s41586-022-05545-9
 
Blessing C, Apelt K, van den Heuvel D, Gonzalez-Leal C, Rother MB, van der Woude M, González-Prieto R, Yifrach A, Parnas A, Shah RG, Kuo TT, Boer DEC, Cai J, Kragten A, Kim HS, Schärer OD, Vertegaal ACO, Shah GM, Adar S, Lans H, van Attikum H, Ladurner AG, Luijsterburg MS (2022) XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair.
Nature Communications 13:4762 10.1038/s41467-022-31820-4  
 
Muniesa-Vargas A, Theil AF, Ribeiro-Silva C, Vermeulen W, Lans H (2022) XPG: a multitasking genome caretaker.
 
Kumar N, Theil AF, Roginskaya V, Ali Y, Calderon M, Watkins SC, Barnes RP, Opresko PL, Pines A, Lans H, Vermeulen W, Van Houten B (2022) Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins.
Nature Communications 13:974 10.1038/s41467-022-28642-9
 
Thijssen KL, van der Woude M, Davó-Martínez C, Dekkers DHW, Sabatella M, Demmers JAA, Vermeulen W, Lans H (2021) C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair.
Communications Biology 4:1336 10.1038/s42003-021-02875-8
 
Geijer ME, Zhou D, Selvam K, Steurer B, Mukherjee C, Evers B, Cugusi S, van Toorn M, van der Woude M, Janssens RC, Kok YP, Gong W, Raams A, Lo CSY, Lebbink JHG, Geverts B, Plummer DA, Bezstarosti K, Theil AF, Mitter R, Houtsmuller AB, Vermeulen W, Demmers JAA, Li S, van Vugt MATM, Lans H, Bernards R, Svejstrup JQ, Ray Chaudhuri A, Wyrick JJ, Marteijn JA. (2021) Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability.
Nature Cell Biology 23:608-619 10.1038/s41556-021-00692-z
 

Lo CSY, van Toorn M, Gaggioli V, Paes Dias M, Zhu Y, Manolika EM, Zhao W, van der Does M, Mukherjee C, G S C Souto Gonçalves J, van Royen ME, French PJ, Demmers J, Smal I, Lans H, Wheeler D, Jonkers J, Chaudhuri AR, Marteijn JA, Taneja N. (2021) SMARCAD1-mediated active replication fork stability maintains genome integrity.

Science Advances 7:eabe7804. 10.1126/sciadv.abe7804

 

Sabatella M, Thijssen KL, Davó-Martínez C, Vermeulen W, Lans H (2021) Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1.
Cell Reports 34:108608 10.1016/j.celrep.2020.108608


Ribeiro-Silva C, Sabatella M, Helfricht A, Marteijn JA, Theil AF, Vermeulen W, Lans H (2020) Ubiquitin and TFIIH-stimulated DDB2 dissociation drives DNA damage handover in nucleotide excision repair.

Nature Communications 11:4868 10.1038/s41467-020-18705-0

 

Sabatella M, Pines A, Slyskova J, Vermeulen W, Lans H (2020) ERCC1-XPF targeting to psoralen-DNA crosslinks depends on XPA and FANCD2.

Cellular Molecular Life Sciences 77:2005-2016 10.1007/s00018-019-03264-5

 

Lans H, Hoeijmakers JHJ, Vermeulen W, Marteijn JA (2019) The DNA damage response to transcription stress.

Nature Reviews Mol Cell Biol 20:766-784 10.1038/s41580-019-0169-4

 

Fang Q, Andrews J, Sharma N, Wilk A, Clark J, Slyskova J, Koczor CA, Lans H, Prakash A, Sobol RW (2019) Stability and sub-cellular localization of DNA polymerase β is regulated by interactions with NQO1 and XRCC1 in response to oxidative stress.

Nucleic Acids Research 47:6269-6286 10.1093/nar/gkz293

 

Borgermann N, Ackermann L, Schwertman P, Hendriks IA, Thijssen K, Liu JC, Lans H, Nielsen ML, Mailand N (2019) SUMOylation promotes protective responses to DNA-protein crosslinks.

EMBO Journal 38:e101496 10.15252/embj.2019101496

 

Ribeiro-Silva C, Vermeulen W, Lans H (2019) SWI/SNF: Complex complexes in genome stability and cancer.

DNA Repair 77:87-95 10.1016/j.dnarep.2019.03.007

 

Riemslagh FW, Lans H, Seelaar H, Severijnen LWFM, Melhem S, Vermeulen W, Aronica E, Pasterkamp RJ, van Swieten JC, Willemsen R (2019) HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis.

Acta Neuropathologica Communications 7:39 10.1186/s40478-019-0694-6

 

Doshi S, Price E, Landis J, Barot U, Sabatella M, Lans H, Kalb RG (2019) Neuropeptide signaling regulates the susceptibility of developing C. elegans to anoxia.

Free Radical Biology and Medicine 131:197-208 10.1016/j.freeradbiomed.2018.12.006

 

Ribeiro-Silva C, Aydin ÖZ, Mesquita-Ribeiro R, Slyskova J, Helfricht A, Marteijn JA, Hoeijmakers JHJ, Lans H, Vermeulen W (2018) DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.

Nature Communications 9:4067 10.1038/s41467-018-06402-y

 

Sabatella M, Theil AF, Ribeiro-Silva C, Slyskova J, Thijssen K, Voskamp C, Lans H, Vermeulen W (2018) Repair protein persistence at DNA lesions characterizes XPF defect with Cockayne syndrome features.

Nucleic Acids Research 46:9563-9577 10.1093/nar/gky774

 

Slyskova J, Sabatella M, Ribeiro-Silva C, Stok C, Theil AF, Vermeulen W, Lans H (2018) Base and nucleotide excision repair facilitate resolution of platinum drugs-induced transcription blockage.

Nucleic Acids Research 46:9537-9549 10.1093/nar/gky764

 

Mandemaker IK, Geijer ME, Kik I, Bezstarosti K, Rijkers E, Raams A, Janssens RC, Lans H, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA (2018) DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones.

EMBO Reports  19:e45566 10.15252/embr.201745566

 

Menoni H, Wienholz F, Theil AF, Janssens RC, Lans H, Campalans A, Radicella JP, Marteijn JA, Vermeulen W (2018) The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage.

Nucleic Acids Research 46:7747-7756 10.1093/nar/gky579

 

Mandemaker IK, van Cuijk L, Janssens RC, Lans H, Bezstarosti K, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA (2017) DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway.

Scientific Reports 7:15353 10.1038/s41598-017-15194-y

 

Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG (2015) Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.

Journal of Neuroscience 35:14286-306 10.1523/JNEUROSCI.0642-15.2015

 

van Cuijk L, van Belle GJ, Turkyilmaz Y, Poulsen SL, Janssens RC, Theil AF, Sabatella M, Lans H, Mailand N, Houtsmuller AB, Vermeulen W, Marteijn JA (2015) SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair

Nature Communications 6:7499 10.1038/ncomms8499

 

Lans H, Vermeulen W (2015) Tissue specific response to DNA damage: C. elegans as role model

DNA Repair 32:141-148 10.1016/j.dnarep.2015.04.025

 

Aydin OZ, Vermeulen W, Lans H (2014) ISWI chromatin remodeling complexes in the DNA damage response

Cell Cycle 13:3016-3025 10.4161/15384101.2014.956551

 

Aydin OZ, Marteijn JA, Ribeiro-Silva C, Rodríguez López A, Wijgers N, Smeenk G, van Attikum H, Poot RA, Vermeulen W, Lans H (2014) Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription

Nucleic Acids Research 42:8473-8485 10.1093/nar/gku565

 

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH (2014) Understanding nucleotide excision repair and its roles in cancer and ageing

Nature Reviews Mol Cell Biol 15:465-81 10.1038/nrm3822

 

Lans H, Lindvall JM, Thijssen K, Karambelas AE, Cupac D, Fensgård O, Jansen G, Hoeijmakers JH, Nilsen H, Vermeulen W. (2013) DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals

Cell Death and Differentiation 20:1709-18 10.1038/cdd.2013.126

 

Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB, Vermeulen W, Marteijn JA (2013) Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage 

Molecular Cell 51:469-79 10.1016/j.molcel.2013.08.007

 

Lans H, Hoeijmakers JH (2013) Genome stability, progressive kidney failure and aging

Nature Genetics 44:836-8 10.1038/ng.2363

 

Lans H, Marteijn JA, Vermeulen W (2012) ATP-dependent chromatin remodeling in the DNA-damage response

Epigenetics and Chromatin 5:4 10.1186/1756-8935-5-4

 

Lans H, Vermeulen W (2011) Nucleotide Excision Repair in Caenorhabditis elegans

Molecular Biology International 2011:542795 10.4061/2011/542795

 

Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W (2010) Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development

PLoS Genetics 6:e1000941 10.1371/journal.pgen.1000941


Marteijn JA, Bekker-Jensen S, Mailand N, Lans H, Schwertman P, Gourdin AM, Dantuma NP, Lukas J, Vermeulen W (2009) Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

Journal of Cell Biology 186:835-47 10.1083/jcb.200902150

Lans H, Dekkers MP, Hukema RK, Bialas NJ, Leroux MR, Jansen G (2009) Signaling proteins that regulate NaCl chemotaxis responses modulate longevity in C. elegans.

Annals of the NY Academy of Sciences 1170:682-7 10.1111/j.1749-6632.2009.04362.x

Luijsterburg MS, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, Warmerdam DO, Lindh M, Brink MC, Dobrucki JW, Aten JA, Fousteri MI, Jansen G, Dantuma NP, Vermeulen W, Mullenders LH, Houtsmuller AB, Verschure PJ, van Driel R (2009) Heterochromatin protein 1 is recruited to various types of DNA damage

Journal of Cell Biology 185:577-86 10.1083/jcb.200810035

 

Zhang D, Lans H, Vermeulen W, Lenferink A, Otto C (2008) Quantitative fluorescence correlation spectroscopy reveals a 1000-fold increase in lifetime of protein functionality

Biophysical Journal 95:3439-46 10.1529/biophysj.108.133215

Alekseev S, Luijsterburg MS, Pines A, Geverts B, Mari PO, Giglia-Mari G, Lans H, Houtsmuller AB, Mullenders LH, Hoeijmakers JH, Vermeulen W (2008) Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.

Molecular and Cellular Biology 28:7402-13 10.1128/MCB.01108-08

 

Lans H, Jansen G (2007) Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans.

Developmental Biology 303:474-82 10.1016/j.ydbio.2006.11.028

 

Lans H, Jansen G. (2006) Noncell- and cell-autonomous G-protein-signaling converges with Ca2+/mitogen-activated protein kinase signaling to regulate str-2 receptor gene expression in Caenorhabditis elegans.

Genetics 173:1287-99 10.1534/genetics.106.058750

 

Lans H, Hoeijmakers JH (2006) Cell biology: ageing nucleus gets out of shape

Nature 440:32-4 10.1038/440032a

 

Lans H, Rademakers S, Jansen G (2004) A network of stimulatory and inhibitory Galpha-subunits regulates olfaction in Caenorhabditis elegans.

Genetics 167:1677-8 10.1534/genetics.103.024786

 

Fukuto HS, Ferkey DM, Apicella AJ, Lans H, Sharmeen T, Chen W, Lefkowitz RJ, Jansen G, Schafer WR, Hart AC (2004) G protein-coupled receptor kinase function is essential for chemosensation in C. elegans.

Neuron 42:581-93 10.1016/s0896-6273(04)00252-1

 

Bontekoe CJ, Bakker CE, Nieuwenhuizen IM, van der Linde H, Lans H, de Lange D, Hirst MC, Oostra BA (2001) Instability of a (CGG)98 repeat in the Fmr1 promoter.

Human Molecular Genetics 10:1693-9 10.1093/hmg/10.16.1693

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